-Always do 'Buy It Now' only with immediate payment required. I'm on a few subreddits about eBay, and it seems non-payment on auctions is pretty rampant. I also do 'Best Offer' too, though surprisingly few people use it. If you set up or revise the item on a browser, you can set up auto-accept and auto-decline amounts on offers so you don't have to do anything. For example, list a game at BIN $19.99 with Best Offer, auto decline anything $14.99 and under and auto accept anything $15.00 and over. Makes life a lot easier, it just stinks that you can only set the auto-decline on the phone app.
-Always do free shipping and let eBay calculate actual shipping (you'll need to weigh and measure your parcels when you are making the listing). It gives you a range so you'll know the maximum that will come out of the sale, so you just factor that into your price. Another reason to do free shipping is, if you don't, the buyer can give you a star rating on "shipping cost" which is nonsense because you can make it so they can't see what you paid for the label. If you do free shipping, they can't rate you on this.