Sore palm.
From the original Mario Party.
There was a mini game where you had to rotate the control stick as fast as you can for an extended period of time. I found that the fastest I could rotate was when I would put the control stick up against my palm and rub it circles with my open hand. It worked, but after a while it started to hurt.
Argh.
ARGH.I honestly can't think of anything too bad. My arms get tired from holding the DS in the air for hours on end
(not so with the oh-so-light Micro). Uh... my ankle starts to hurt a lot when I play DDR for too long. I've gotten shocked by the plug of a DDR pad. Beyond all that, no.
Heh i have electrocuted so many times it is rediculous.
A few times it has been videogame related.
More often than not it is cable box related though.
For some reason it seems that many of them arn't grounded properly.